Studies on L - Tyrosine O - Sulphate 2 . IDENTIFICATION OF p - HYDROXYPHENYLPYRUVIC ACID [ 35 S ] SULPHATE AS A METABOLITE OF L - TYROSINE O [ 35 S ] - SULPHATE IN THE RAT BY GILLIAN
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چکیده
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Biosynthesis of L-tyrosine O-sulphate from the Methyl and Ethyl Esters of L-tyrosine.
1. Rat-liver supernatant preparations are capable of achieving the biological sulphation of l-tyrosine methyl ester, the reaction proceeding maximally at a substrate concentration of 30 mm and at pH 7.0. 2. Two sulphated products are formed, one of which has been identified as l-tyrosine O-sulphate. On the basis of indirect evidence the other product can be assumed to be l-tyrosine O-sulphate m...
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1. The preparation of potassium l-serylglycine O-sulphate and the corresponding (35)S-labelled ester is described. 2. Intraperitoneal injection of potassium l-serylglycine O[(35)S]-sulphate to rats results in about 75% of the radioactivity of the dose appearing in the urine within 48hr. Almost 72% of the radioactivity recovered in the urine was in the form of inorganic [(35)S]sulphate. 3. Analy...
متن کاملThe detection and determination of L-tyrosine O-sulphate in rabbit and other mammalian urine.
A sensitive method using the Technicon Amino Acid Autoanalyzer was developed for the determination of l-tyrosine O-sulphate in mammalian urine. Normal rabbit urine was shown to contain a material that has properties identical with l-tyrosine O-sulphate. The material is also a normal constituent of rat, sheep, calf and mouse urine and is excreted by these animals in quantities ranging from 0.1 t...
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The metabolic fate of [1-14-C]hexadecylsulphate and hexadecyl[35-S]sulphate, administered intravenously as the sodium and trimethylammonium salt to dogs and orally as the erythromycin salt to dogs, rats and humans, was studied. Studies with rats indicated that the compounds were well absorbed and rapidly excreted in the urine. However, after oral administration of the 14-C-and 35-S-labelled hex...
متن کاملThe metabolism of potassium dodecyl [35-S]sulphate in the rat.
The metabolic fate of potassium dodecyl [(35)S]sulphate was studied in rats. Intraperitoneal and oral administration of the ester into free-ranging animals were followed by the excretion of the bulk of the radioactivity in the urine within 12hr., approximately 17% being eliminated as inorganic [(35)S]sulphate. Similar results were obtained in experiments in which potassium dodecyl [(35)S]sulpha...
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